Bioactive Small Molecules
Cayman Chemical GInsenosIde Rd 5mg
A protopanaxadiol that has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions
Cayman Chemical ANTIBODY KW 2478 1mg
An Hsp90 inhibitor (IC50 = 3.8 nM for Hsp90α); inhibits the growth of OPM-2/GFP, KMS011, RPMI 8226, and NCI-H929 multiple myeloma cells (GI50s = 0.3, 0.34, 0.39, and 0.12 μM, respectively) and Raji, SR, and SC-1 non-Hodgkin's lymphoma cells (GI50s = 0.39, 0.098, and 0.33 μM, respectively); decreases expression of IGF-IRβ and c-RAF-1 and induces apoptosis in OPM-2/GFP and NCI-H929 cells; reduces IGF-IRβ, c-RAF-1, Cdk9, and phosphorylated ERK1/2 protein levels in tumor tissue and decreases tumor growth in an NCI-H929 mouse xenograft model at 100 mg/kg
TARGETMOL CHEMICALS INC SELODENOSON 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Selodenoson (RG-14202) is a selective adenosine A1 receptor agonist used to slow the heart rate in patients with atrial fibrillation and to treat arrhythmias. purity: 99%
Medchemexpress LLC HY-136424 5mg Medchemexpress, GPI-1485 CAS:186268-78-0 Purity:>98%
Medchemexpress, HY-136424 5mg GPI-1485 CAS:186268-78-0 GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-137498 5mg Medchemexpress, EBOV/MARV-IN-1 CAS:2479465-67-1 Purity:>98%
Medchemexpress, HY-137498 5mg EBOV/MARV-IN-1 CAS:2479465-67-1 EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC KPLH1130 | 906669-07-6 | 99.9% | 1 ML
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. It inhibits M1 macrophage polarization by decreasing pro-inflammatory cytokines and reducing M1 phenotype markers. It prevents the decrease in mitochondrial oxygen consumption rate caused by inflammatory stimuli and improves glucose tolerance in mice fed a high-fat diet. This compound is useful for studying obesity-associated metabolic disorders and inflammatory conditions.
- Inhibits M1 macrophage polarization
- Decreases expression of pro-inflammatory cytokines
- Reduces M1 phenotype markers (HIF-1α, iNOS)
- Lowers nitric oxide (NO) production
- Prevents decrease in mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli
- Improves glucose tolerance in high-fat diet-fed mice
- Useful for studying obesity-associated metabolic disorders
- Useful for studying inflammatory conditions
TARGETMOL CHEMICALS INC BRIVANIB ALANINATE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2 a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis inhibition of tumor cell growth and tumor regression. purity: 99%
![Medchemexpress LLC N-[(1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxypentan-2-yl]-2-oxo-1,3-dihydroindole-4-carboxamide | 2406205-61-4 | 99.8% | C21H23FN2O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260083.png-250.jpg)
Medchemexpress LLC N-[(1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxypentan-2-yl]-2-oxo-1,3-dihydroindole-4-carboxamide | 2406205-61-4 | 99.8% | C21H23FN2O3 | 10MG
A1AT modulator 1 is a small-molecule inhibitor of Z α1-antitrypsin polymerization with reported potency (pIC50 = 8.3). The compound is supplied as a white to off-white solid for research use, has molecular formula C21H23FN2O3, molecular weight 370.42 g/mol, and an analytical purity of approximately 99.8%.
- Exhibits potent inhibition of Z α1-antitrypsin polymerization (pIC50 = 8.3).
- High analytical purity suitable for in vitro research.
- Supplied as a solid in small milligram pack sizes for assay flexibility.
- Storage recommendations provided for powder and solution to preserve stability.
- Applicable to biochemical and cell-based studies of serpin modulation.
Medchemexpress LLC HY-139643 5mg , CXCR7 antagonist-1 CAS:1613021-99-0 Purity:>98%
HY-139643 5mg CXCR7 antagonist-1 CAS: 1613021-99-0 CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY M50054 25mg
A cell-permeable inhibitor of caspase-3 activation; blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide
Cayman Chemical ANTIBODY PsoralIdIn 10mg
A furanocoumarin isolated from the seeds of P. corylifolia that has been shown to induce cytotoxicity against various cancer cells through TRAIL-mediated events
Selleck Chemical LLC Marinopyrrole A (Maritoclax) 5mg 1227962-62-0
Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC A 83-01 50MG
Also available in 5 mg 10 mg and bulk. Please contact Fisher for quotes. A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-(beta) type I receptor ALK5 kinase type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM 45 nM and 7.5 nM respectively. purity: 98%
Cayman Chemical ANTIBODY T-705 100mg
An antiviral agent; inhibits influenza A, B, and C (IC50s = 0.013-0.48 UG/ml); inhibits a GS4071-resistant influenza strain (IC50 = 0.095 UG/ml) and RNA viruses (IC50s = 4.8-41 UG/ml); not active against DNA viruses; undergoes phosphoribosylation to form T-705-RTP, the active form; decreases the rate of mortality in influenza-infected mice when used at a dose of 200 mg/kg once daily; reduces the lung virus yield in a dose-dependent manner at doses ranging from 50-200 mg/kg per day in influenza-infected mice